human POLR1A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human POLR1A.
shAAV-219376
AAV-h-POLR1A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human POLR1A (RNA polymerase I subunit A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A190; AFDCIN; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; DNA-directed RNA polymerase I subunit A1; DNA-directed RNA polymerase I subunit RPA1; polymerase (RNA) I polypeptide A, 194kDa; polymerase (RNA) I subunit A; RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A1; RPA1; RPA194; RPO14; RPO1-4
Description (eCommerce)
POLR1A is a DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is the largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95602].
Gene ID
25885
Gene Name (eCommerce)
RNA polymerase I subunit A
Gene Name (Vector)
RNA polymerase I subunit A
Gene Symbol
POLR1A
HGNC ID
HGNC:17264
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5163
ORF Size (bp)
5163 bp
Protein Name (eCommerce)
DNA-directed RNA polymerase I subunit RPA1
RefSeq ID
NM_015425
RefSeq Synonyms
NM_015425, BC143345, BC126303, BC117173,
Research Areas
Cancer,Epigenetic Regulation of Gene Expression,Gene Expression,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cancer,cell_biology,genetics,signal_transduction
Species
human
Target Sentence
POLR1A is a DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is the largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95602].
UniGene ID
Hs.531818
UniProt ID (eCommerce)
O95602
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.