human POLG shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human POLG.
shAAV-219364
AAV-h-POLG-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human POLG (DNA polymerase gamma, catalytic subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MDP1; MIRAS; MTDPS4A; MTDPS4B; PEO; POLG1; POLGA; SANDO; SCAE
Description (Vector)
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Gene ID
5428
Gene Name (Vector)
DNA polymerase gamma, catalytic subunit
Gene Symbol
POLG
HGNC ID
HGNC:9179
ORF Size (aa)
3720
ORF Size (bp)
3720 bp
RefSeq ID
NM_002693
RefSeq Synonyms
NM_002693, NM_001126131, BC050559, BC042571,
Species
human
UniGene ID
Hs.706868
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.