human PNPLA6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PNPLA6.
shAAV-219319
AAV-h-PNPLA6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PNPLA6 (patatin like phospholipase domain containing 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BNHS; iPLA2delta; LNMS; NTE; NTEMND; OMCS; SPG39; sws
Description (Vector)
PNPLA6 encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
10908
Gene Name (Vector)
patatin like phospholipase domain containing 6
Gene Symbol
PNPLA6
HGNC ID
HGNC:16268
ORF Size (aa)
3984
ORF Size (bp)
3984 bp
RefSeq ID
NM_006702
RefSeq Synonyms
NM_006702, NM_001166114, NM_001166113, NM_001166112, NM_001166111, BC051768, BC050553,
Species
human
UniGene ID
Hs.631863
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.