human PLP1 shRNA silencing AAV

Name
AAV-h-PLP1-shRNA

Cat No
shAAV-219222

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PLP1.

shAAV-219222

AAV-h-PLP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLP1 (proteolipid protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; SPG2

Description (Vector)

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Gene ID

5354

Gene Name (Vector)

proteolipid protein 1

Gene Symbol

PLP1

HGNC ID

HGNC:9086

ORF Size (aa)

729

RefSeq ID

NM_000533

RefSeq Synonyms

NM_199478, NM_001305004, NM_001128834, NM_000533, BC095452, BC002665,

Species

human

UniGene ID

Hs.1787

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.