human PLEKHG4 shRNA silencing AAV

Name
AAV-h-PLEKHG4-shRNA

Cat No
shAAV-219183

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PLEKHG4.

shAAV-219183

AAV-h-PLEKHG4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARHGEF44; PRTPHN1; SCA4

Description (Vector)

PLEKHG4 contains multiple domains suggestive of a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Mutations in this gene are associated with spinocerebellar ataxia 16q22-linked. Several alternatively spliced transcript variants, differing only in the 5' UTR, or encoding a different isoform, have been found for this gene.

Gene ID

25894

Gene Name (Vector)

pleckstrin homology and RhoGEF domain containing G4

Gene Symbol

PLEKHG4

HGNC ID

HGNC:24501

ORF Size (aa)

3456

ORF Size (bp)

3456 bp

RefSeq ID

NM_015432

RefSeq Synonyms

NM_015432, NM_001129731, NM_001129729, NM_001129728, NM_001129727, BC082974, BC063501, BC054486,

Species

human

UniGene ID

Hs.188781

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.