human PLEKHA1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PLEKHA1.
shAAV-219156
AAV-h-PLEKHA1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PLEKHA1 (pleckstrin homology domain containing A1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PH domain-containing family A member 1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; pleckstrin homology domain-containing family A member 1; tandem PH domain-containing protein 1; TAPP1; TAPP-1
Description (eCommerce)
Pleckstrin homology domain containing A1 (PLECKHA1) binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. PLECKHA1 may recruit other proteins to the plasma membrane. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HB21].
Description (Vector)
PLEKHA1 encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
Gene ID
59338
Gene Name (eCommerce)
pleckstrin homology domain containing A1
Gene Name (Vector)
pleckstrin homology domain containing A1
Gene Symbol
PLEKHA1
HGNC ID
HGNC:14335
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1215
ORF Size (bp)
1215 bp
Protein Name (eCommerce)
Pleckstrin homology domain-containing family A member 1
RefSeq ID
NM_021622
RefSeq Synonyms
NM_021622, NM_001330178, NM_001195608, NM_001001974, BC042458, BC001136,
Research Areas
B-cell Receptor Signaling,Immunology,Signal Transduction,Spermatogenesis
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,signal_transduction
Species
human
Target Sentence
Pleckstrin homology domain containing A1 (PLECKHA1) binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. PLECKHA1 may recruit other proteins to the plasma membrane. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HB21].
UniGene ID
Hs.643512
UniProt ID (eCommerce)
Q9HB21
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.