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human PLAGL1 shRNA silencing AAV

Name 
AAV-h-PLAGL1-shRNA
Cat No 
shAAV-219101
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PLAGL1.

shAAV-219101
AAV-h-PLAGL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLAGL1 (PLAG1 like zinc finger 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LOT1; ZAC; ZAC1
Description (Vector)
PLAGL1 encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). PLAGL1 is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.
Gene ID
5325
Gene Name (Vector)
PLAG1 like zinc finger 1
Gene Symbol
PLAGL1
HGNC ID
HGNC:9046
ORF Size (aa)
1392
ORF Size (bp)
1392 bp
RefSeq ID
NM_002656
RefSeq Synonyms
NM_006718, NM_002656, NM_001317162, NM_001317161, NM_001317160, NM_001317159, NM_001317158, NM_001317157, NM_001317156, NM_001289049, NM_001289048, NM_001289047, NM_001289046, NM_001289045, NM_001289044, NM_001289043, NM_001289042, NM_001289041, NM_001289040, NM_001289039, NM_001289038, NM_001289037, NM_001080956, NM_001080955, NM_001080954, NM_001080953, NM_001080952, NM_001080951, BC109086, BC109085, BC074814,
Species
human
UniGene ID
Hs.715495

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.