human PLA2G2A shRNA silencing AAV

Name
AAV-h-PLA2G2A-shRNA

Cat No
shAAV-219065

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PLA2G2A.

shAAV-219065

AAV-h-PLA2G2A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLA2G2A (phospholipase A2 group IIA). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2

Description (Vector)

PLA2G2A is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.

Gene ID

5320

Gene Name (Vector)

phospholipase A2 group IIA

Gene Symbol

PLA2G2A

HGNC ID

HGNC:9031

ORF Size (aa)

435

RefSeq ID

NM_000300

RefSeq Synonyms

NM_001161729, NM_001161728, NM_001161727, NM_000300, BC005919,

Species

human

UniGene ID

Hs.466804

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.