human PKN1 shRNA silencing AAV

Name
AAV-h-PKN1-shRNA

Cat No
shAAV-219040

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PKN1.

shAAV-219040

AAV-h-PKN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PKN1 (protein kinase N1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1

Description (Vector)

PKN1 belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene ID

5585

Gene Name (Vector)

protein kinase N1

Gene Symbol

PKN1

HGNC ID

HGNC:9405

ORF Size (aa)

1812

ORF Size (bp)

1812 bp

RefSeq ID

NM_002741

RefSeq Synonyms

NM_213560, NM_002741, BC094766, BC040061,

Species

human

UniGene ID

Hs.466044

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.