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human PKMYT1 shRNA silencing AAV

Name 
AAV-h-PKMYT1-shRNA
Cat No 
shAAV-219038
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PKMYT1.

shAAV-219038
AAV-h-PKMYT1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; myt1 kinase; PPP1R126; protein phosphatase 1, regulatory subunit 126
Description (eCommerce)
MYT1 (membrane associated tyrosine/threonine protein kinase 1) is is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. MYT is associated with the membrane throughout the cell cycle, and its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of MYT1 [taken from NCBI Entrez Gene (GeneID:9088)].
Description (Vector)
PKMYT1 encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
9088
Gene Name (eCommerce)
protein kinase, membrane associated tyrosine/threonine 1
Gene Name (Vector)
protein kinase, membrane associated tyrosine/threonine 1
Gene Symbol
PKMYT1
HGNC ID
HGNC:29650
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1443
ORF Size (bp)
1443 bp
Protein Name (eCommerce)
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
RefSeq ID
NM_004203
RefSeq Synonyms
NM_182687, NM_004203, NM_001258451, NM_001258450, BC160025,
Research Areas
Cell Cycle,Golgi Apparatus,Kinase/Phosphatase,Meiosis
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,signal_transduction
Species
human
Target Sentence
MYT1 (membrane associated tyrosine/threonine protein kinase 1) is is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. MYT is associated with the membrane throughout the cell cycle, and its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of MYT1 [taken from NCBI Entrez Gene (GeneID:9088)].
UniGene ID
Hs.77783
UniProt ID (eCommerce)
Q99640

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.