human PEX7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PEX7.
shAAV-218650
AAV-h-PEX7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PEX7 (peroxisomal biogenesis factor 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PBD9B; PTS2R; RCDP1; RD
Description (Vector)
PEX7 encodes the cytosolic receptor for the set of peroxisomal matrix enzymes targeted to the organelle by the peroxisome targeting signal 2 (PTS2). Defects in this gene cause peroxisome biogenesis disorders (PBDs), which are characterized by multiple defects in peroxisome function. There are at least 14 complementation groups for PBDs, with more than one phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene have been associated with PBD complementation group 11 (PBD-CG11) disorders, rhizomelic chondrodysplasia punctata type 1 (RCDP1), and Refsum disease (RD).
Gene ID
5191
Gene Name (Vector)
peroxisomal biogenesis factor 7
Gene Symbol
PEX7
HGNC ID
HGNC:8860
ORF Size (aa)
843
RefSeq ID
NM_000288
RefSeq Synonyms
NM_000288, BC031606, BC006268,
Species
human
UniGene ID
Hs.280932
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.