human PDZD3 shRNA silencing AAV

Name
AAV-h-PDZD3-shRNA

Cat No
shAAV-218573

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDZD3.

shAAV-218573

AAV-h-PDZD3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDZD3 (PDZ domain containing 3). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

IKEPP; NHERF4; PDZK2

Description (Vector)

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 (PubMed 11950846)).(supplied by OMIM, Mar 2008)

Gene ID

79849

Gene Name (Vector)

PDZ domain containing 3

Gene Symbol

PDZD3

HGNC ID

HGNC:19891

ORF Size (aa)

1476

ORF Size (bp)

1476 bp

RefSeq ID

NM_024791

RefSeq Synonyms

NM_024791, NM_001168468, BC029042,

Species

human

UniGene ID

Hs.374726

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.