human PDYN shRNA silencing AAV

Name
AAV-h-PDYN-shRNA

Cat No
shAAV-218570

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDYN.

shAAV-218570

AAV-h-PDYN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDYN (prodynorphin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADCA; PENKB; SCA23

Description (Vector)

PDYN is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene ID

5173

Gene Name (Vector)

prodynorphin

Gene Symbol

PDYN

HGNC ID

HGNC:8820

ORF Size (aa)

765

RefSeq ID

NM_024411

RefSeq Synonyms

NM_024411, NM_001190900, NM_001190899, NM_001190898, NM_001190892, BC026334,

Species

human

UniGene ID

Hs.22584

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.