human PDS5B shRNA silencing AAV

Name 
AAV-h-PDS5B-shRNA
Cat No 
shAAV-218556
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDS5B.

shAAV-218556
AAV-h-PDS5B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDS5B (PDS5 cohesin associated factor B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
androgen induced inhibitor of proliferation; androgen-induced proliferation inhibitor; androgen-induced prostate proliferative shutoff-associated protein AS3; androgen-induced shutoff 3; APRIN; AS3; CG008; sister chromatid cohesion protein PDS5 homolog B
Description (eCommerce)
Pds5B is a cohesin interacting protein. Cohesin functions to hold sister chromatids together during meiosis and mitosis and ensures proper segregation of chromosomes. Pds5B may play a specific role in the stabilization and destabilization of cohesin-mediated cohesion. Pds5B expression has been demonstrated to be androgen-induced and mediate the androgen-induced proliferative arrest of human prostate cells.
Description (Vector)
PDS5B encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.
Gene ID
23047
Gene Name (eCommerce)
PDS5 cohesin associated factor B
Gene Name (Vector)
PDS5 cohesin associated factor B
Gene Symbol
PDS5B
HGNC ID
HGNC:20418
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4341
ORF Size (bp)
4341 bp
Protein Name (eCommerce)
Sister chromatid cohesion protein PDS5 homolog B
RefSeq ID
NM_015032
RefSeq Synonyms
NM_015032, BC172246, BC070274, BC039256,
Research Areas
Cell Cycle,Cell Division
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Pds5B is a cohesin interacting protein. Cohesin functions to hold sister chromatids together during meiosis and mitosis and ensures proper segregation of chromosomes. Pds5B may play a specific role in the stabilization and destabilization of cohesin-mediated cohesion. Pds5B expression has been demonstrated to be androgen-induced and mediate the androgen-induced proliferative arrest of human prostate cells.
UniGene ID
Hs.716441
UniProt ID (eCommerce)
Q9NTI5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.