human PDCD4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PDCD4.
shAAV-218441
AAV-h-PDCD4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PDCD4 (programmed cell death 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
H731; neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4; protein 197/15a
Description (eCommerce)
Programmed cell death 4 (PDCD4) has been identified as a tumor suppressor that is able to inhibit tumor invasion and neoplastic transformation. The tumor suppressor activity of PDCD4 is achieved via its ability to inhibit translation initiation of proteins essential for transformation and tumor invasion. PDCD4A inhibits translation by interacting with the RNA helicase eIF4A and the scaffolding protein eIF4G.
Description (Vector)
PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
Gene ID
27250
Gene Name (eCommerce)
programmed cell death 4
Gene Name (Vector)
programmed cell death 4
Gene Symbol
PDCD4
HGNC ID
HGNC:8763
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1410
ORF Size (bp)
1410 bp
Protein Name (eCommerce)
Programmed cell death protein 4
RefSeq ID
NM_014456
RefSeq Synonyms
NM_145341, NM_014456, NM_001199492, BC031049, BC026104,
Research Areas
Aging,Apoptosis,Cancer,Cell Cycle,IFN Signaling,Immunology,JNK Signaling,MicroRNAs in Cancer,mTOR Signaling,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Programmed cell death 4 (PDCD4) has been identified as a tumor suppressor that is able to inhibit tumor invasion and neoplastic transformation. The tumor suppressor activity of PDCD4 is achieved via its ability to inhibit translation initiation of proteins essential for transformation and tumor invasion. PDCD4A inhibits translation by interacting with the RNA helicase eIF4A and the scaffolding protein eIF4G.
UniGene ID
Hs.711490
UniProt ID (eCommerce)
Q53EL6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.