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human PCDH15 shRNA silencing AAV

Name 
AAV-h-PCDH15-shRNA
Cat No 
shAAV-218323
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PCDH15.

shAAV-218323
AAV-h-PCDH15-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PCDH15 (protocadherin related 15). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDHR15; DFNB23; USH1F
Description (Vector)
PCDH15 is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.
Gene ID
65217
Gene Name (Vector)
protocadherin related 15
Gene Symbol
PCDH15
HGNC ID
HGNC:14674
ORF Size (aa)
5865
ORF Size (bp)
5865 bp
RefSeq ID
NM_033056
RefSeq Synonyms
NM_033056, NM_001142773, NM_001142772, NM_001142771, NM_001142770, NM_001142769, NM_001142768, NM_001142767, NM_001142766, NM_001142765, NM_001142764, NM_001142763, BC156450,
Species
human
UniGene ID
Hs.280209

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.