human PAPOLA shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PAPOLA.
shAAV-218193
AAV-h-PAPOLA-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PAPOLA (poly(A) polymerase alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PAP; PAP-alpha; poly(A) polymerase alpha; polynucleotide adenylyltransferase alpha
Description (eCommerce)
Poly(A) polymerase alpha (PAPOLA) is the polymerase responsible for catalyzing the addition of adenosine to the 3’end of pre-mRNAs for the synthesis of the 3’-end poly(A) tail. PAPOLA associates with the cleavage and polyadenylation specificity factor (CPSF) and Fip1 to perform this function.
Description (Vector)
PAPOLA belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
10914
Gene Name (eCommerce)
poly(A) polymerase alpha
Gene Name (Vector)
poly(A) polymerase alpha
Gene Symbol
PAPOLA
HGNC ID
HGNC:14981
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2238
ORF Size (bp)
2238 bp
Protein Name (eCommerce)
Poly(A) polymerase alpha
RefSeq ID
NM_032632
RefSeq Synonyms
NM_032632, NM_001293632, NM_001293628, NM_001293627, NM_001252007, NM_001252006, BC036014, BC000927,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Signal Transduction,Spliceosome,TNF Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
Poly(A) polymerase alpha (PAPOLA) is the polymerase responsible for catalyzing the addition of adenosine to the 3’end of pre-mRNAs for the synthesis of the 3’-end poly(A) tail. PAPOLA associates with the cleavage and polyadenylation specificity factor (CPSF) and Fip1 to perform this function.
UniGene ID
Hs.253726
UniProt ID (eCommerce)
P51003
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.