human PALB2 shRNA silencing AAV

Name 
AAV-h-PALB2-shRNA
Cat No 
shAAV-218161
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PALB2.

shAAV-218161
AAV-h-PALB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PALB2 (partner and localizer of BRCA2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FANCN; mutant partner and localizer of BRCA2; partner and localizer of BRCA2; PNCA3
Description (eCommerce)
PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.
Description (Vector)
PALB2 encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
Gene ID
79728
Gene Name (eCommerce)
partner and localizer of BRCA2
Gene Name (Vector)
partner and localizer of BRCA2
Gene Symbol
PALB2
HGNC ID
HGNC:26144
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3561
ORF Size (bp)
3561 bp
Protein Name (eCommerce)
Partner and localizer of BRCA2
RefSeq ID
NM_024675
RefSeq Synonyms
NM_024675, BC044254,
Research Areas
Apoptosis,Cancer,DNA Damage/Repair,Fanconi anemia,Homologous Recombination,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.
UniGene ID
Hs.444664
UniProt ID (eCommerce)
Q86YC2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.