human PADI1 shRNA silencing AAV

Name
AAV-h-PADI1-shRNA

Cat No
shAAV-218112

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PADI1.

shAAV-218112

AAV-h-PADI1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PADI1 (peptidyl arginine deiminase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HPAD10; PAD1; PDI; PDI1

Description (Vector)

PADI1 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. PADI1 exists in a cluster with four other paralogous genes.

Gene ID

29943

Gene Name (Vector)

peptidyl arginine deiminase 1

Gene Symbol

PADI1

HGNC ID

HGNC:18367

ORF Size (aa)

1992

ORF Size (bp)

1992 bp

RefSeq ID

NM_013358

RefSeq Synonyms

NM_013358, BC136402, BC130574,

Species

human

UniGene ID

Hs.412941

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.