human P2RX7 shRNA silencing AAV

Name
AAV-h-P2RX7-shRNA

Cat No
shAAV-218051

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human P2RX7.

shAAV-218051

AAV-h-P2RX7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human P2RX7 (purinergic receptor P2X 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

P2X7

Description (Vector)

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Gene ID

5027

Gene Name (Vector)

purinergic receptor P2X 7

Gene Symbol

P2RX7

HGNC ID

HGNC:8537

ORF Size (aa)

1278

ORF Size (bp)

1278 bp

RefSeq ID

NM_002562

RefSeq Synonyms

NM_002562, BC011913, BC007679,

Species

human

UniGene ID

Hs.507102

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.