human OXSR1 shRNA silencing AAV

Name 
AAV-h-OXSR1-shRNA
Cat No 
shAAV-218031
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human OXSR1.

shAAV-218031
AAV-h-OXSR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human OXSR1 (oxidative stress responsive 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
OSR1; oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1
Description (eCommerce)
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
Description (Vector)
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
Gene ID
9943
Gene Name (eCommerce)
oxidative stress responsive 1
Gene Name (Vector)
oxidative stress responsive 1
Gene Symbol
OXSR1
HGNC ID
HGNC:8508
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1584
ORF Size (bp)
1584 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase OSR1
RefSeq ID
NM_005109
RefSeq Synonyms
NM_005109, BC008726,
Research Areas
Kinase/Phosphatase,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
UniGene ID
Hs.475970
UniProt ID (eCommerce)
O95747

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.