human OTC shRNA silencing AAV

Name
AAV-h-OTC-shRNA

Cat No
shAAV-217979

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human OTC.

shAAV-217979

AAV-h-OTC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human OTC (ornithine carbamoyltransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

OCTD

Description (Vector)

This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.

Gene ID

5009

Gene Name (Vector)

ornithine carbamoyltransferase

Gene Symbol

OTC

HGNC ID

HGNC:8512

ORF Size (aa)

1065

RefSeq ID

NM_000531

RefSeq Synonyms

NM_000531, BC114496, BC107154, BC107153, BC074745,

Species

human

UniGene ID

Hs.117050

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.