human EIF4A3 Over-expression AAV
This is an AAV expressing Human EIF4A3.
AAV-207771
AAV-h-EIF4A3
Ready-to-use AAV expressing Human EIF4A3 (eukaryotic translation initiation factor 4A3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DDX48; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; eIF4AIII; eIF-4A-III; eIF4A-III; eukaryotic initiation factor 4A-III; eukaryotic initiation factor 4A-like NUK-34; eukaryotic translation initiation factor 4A; Eukaryotic translation initiation factor 4A isoform 3; Fal1; hNMP 265; MUK34; NMP 265; NMP265; nuclear matrix protein 265; NUK34; RCPS
Description (eCommerce)
Eukaryotic initiation factor 4A-III is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. eIF4AIII is an ATP-dependent helicase and a component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.
Description (Vector)
EIF4A3 encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.
Gene ID
9775
Gene Name (eCommerce)
eukaryotic translation initiation factor 4A3
Gene Name (Vector)
eukaryotic translation initiation factor 4A3
Gene Symbol
EIF4A3
HGNC ID
HGNC:18683
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1236
ORF Size (bp)
1236 bp
Protein Name (eCommerce)
Eukaryotic initiation factor 4A-III
RefSeq ID
NM_014740
RefSeq Synonyms
NM_014740, BC011151, BC004386, BC003662,
Research Areas
Cytokine Signaling,Gene Expression,Helicase Activity,Host-Virus Interactions,IFN Signaling,Immunology,mRNA Processing,mRNA Splicing,mRNA transport,RNA Binding,RNA Processing,RNA Transport,Signal Transduction,Spliceosome,Translational Control
Research Areas (Faceted)
signal_transduction,immunology,genetics,transcription_translation,cell_biology,infectious_disease,immunology,signal_transduction,genetics,transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Eukaryotic initiation factor 4A-III is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. eIF4AIII is an ATP-dependent helicase and a component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.
UniGene ID
Hs.389649
UniProt ID (eCommerce)
P38919
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.