human ODF2 shRNA silencing AAV

Name 
AAV-h-ODF2-shRNA
Cat No 
shAAV-217352
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ODF2.

shAAV-217352
AAV-h-ODF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ODF2 (outer dense fiber of sperm tails 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cancer/testis antigen 134; Cenexin; cenexin 1; CT134; ODF2/1; ODF2/2; ODF84; Outer dense fiber of sperm tails protein 2; outer dense fiber of sperm tails, 84-kD; outer dense fiber protein 2; sperm tail structural protein; testis tissue sperm-binding protein Li 51e
Description (eCommerce)
Outer dense fiber protein 2 (ODF2) seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. ODF2 functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. ODF2 is a component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes and is required for the formation and/or maintenance of normal CETN1 assembly [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5BJF6].
Description (Vector)
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers.
Gene ID
4957
Gene Name (eCommerce)
outer dense fiber of sperm tails 2
Gene Name (Vector)
outer dense fiber of sperm tails 2
Gene Symbol
ODF2
HGNC ID
HGNC:8114
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2292
ORF Size (bp)
2292 bp
Protein Name (eCommerce)
Outer dense fiber protein 2
RefSeq ID
NM_002540
RefSeq Synonyms
NM_153440, NM_153439, NM_153437, NM_153436, NM_153435, NM_153433, NM_153432, NM_002540, NM_001242354, NM_001242353, NM_001242352, BC091500, BC010629,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,PLK1 Signaling,Signal Transduction,Spermatogenesis
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,signal_transduction
Species
human
Target Sentence
Outer dense fiber protein 2 (ODF2) seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. ODF2 functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. ODF2 is a component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes and is required for the formation and/or maintenance of normal CETN1 assembly [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5BJF6].
UniGene ID
Hs.129055
UniProt ID (eCommerce)
Q5BJF6

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.