human NUP35 shRNA silencing AAV

Name 
AAV-h-NUP35-shRNA
Cat No 
shAAV-217244
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NUP35.

shAAV-217244
AAV-h-NUP35-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUP35 (nucleoporin 35). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
35 kDa nucleoporin; mitotic phosphoprotein 44; MP44; MP-44; NP44; nuclear pore complex protein Nup53; nucleoporin 35kDa; nucleoporin NUP35; nucleoporin NUP53; NUP53
Description (eCommerce)
The nuclear pore complex (NPC) is a structure that spans the nuclear envelope and provides a conduit between the nucleus and cytoplasm for the nucleocytoplasmic transport of macromolecules. The main components of the NPC are nucleoporins. There are about 30 different human Nups that have been identified. Human Nup35 is the 35 kDa ortholog of the yeast Nup53p. Nup35 is also referred to as Nup53 or vertebrate Nup53. Nup35 is a component of a NPC subcomplex that contains Nup35, Nup93, Nup155, and Nup205.
Description (Vector)
NUP35 encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC.
Gene ID
129401
Gene Name (eCommerce)
nucleoporin 35
Gene Name (Vector)
nucleoporin 35
Gene Symbol
NUP35
HGNC ID
HGNC:29797
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
981
ORF Size (bp)
981 bp
Protein Name (eCommerce)
Nucleoporin NUP53
RefSeq ID
NM_138285
RefSeq Synonyms
NM_138285, NM_001287585, NM_001287584, BC061698, BC047029,
Research Areas
Cell Cycle,Cytoskeleton,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,immunology,metabolism
Species
human
Target Sentence
The nuclear pore complex (NPC) is a structure that spans the nuclear envelope and provides a conduit between the nucleus and cytoplasm for the nucleocytoplasmic transport of macromolecules. The main components of the NPC are nucleoporins. There are about 30 different human Nups that have been identified. Human Nup35 is the 35 kDa ortholog of the yeast Nup53p. Nup35 is also referred to as Nup53 or vertebrate Nup53. Nup35 is a component of a NPC subcomplex that contains Nup35, Nup93, Nup155, and Nup205.
UniGene ID
Hs.180591
UniProt ID (eCommerce)
Q8NFH5

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.