human NUFIP1 shRNA silencing AAV

Name 
AAV-h-NUFIP1-shRNA
Cat No 
shAAV-217225
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NUFIP1.

shAAV-217225
AAV-h-NUFIP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUFIP1 (NUFIP1, FMR1 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bA540M5.1; nuclear FMRP-interacting protein 1; nuclear fragile X mental retardation protein interacting protein 1; nuclear fragile X mental retardation-interacting protein 1; NUFIP; NUFIP1, FMR1 interacting protein 1
Description (eCommerce)
Nuclear FMRP interacting protein 1 (NUFIP1) was identified as a RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. NUFIP1 is a RNA-binding protein and has been shown to shuttle between the nucleus and cytoplasm and may be involved in the export and localization of mRNA.
Description (Vector)
NUFIP1 encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12.
Gene ID
26747
Gene Name (eCommerce)
nuclear FMR1 interacting protein 1
Gene Name (Vector)
NUFIP1, FMR1 interacting protein 1
Gene Symbol
NUFIP1
HGNC ID
HGNC:8057
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
831
Protein Name (eCommerce)
Nuclear fragile X mental retardation-interacting protein 1
RefSeq ID
NM_012345
RefSeq Synonyms
NM_012345, BC017745,
Research Areas
Neurobiology,Nuclear Import/Export,RNA Binding,RNA Processing,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
neurobiology,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Nuclear FMRP interacting protein 1 (NUFIP1) was identified as a RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. NUFIP1 is a RNA-binding protein and has been shown to shuttle between the nucleus and cytoplasm and may be involved in the export and localization of mRNA.
UniGene ID
Hs.525006
UniProt ID (eCommerce)
Q9UHK0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.