human NR4A2 shRNA silencing AAV

Name
AAV-h-NR4A2-shRNA

Cat No
shAAV-217058

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NR4A2.

shAAV-217058

AAV-h-NR4A2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NR4A2 (nuclear receptor subfamily 4 group A member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HZF-3; NOT; NURR1; RNR1; TINUR

Description (Vector)

NR4A2 encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene ID

4929

Gene Name (Vector)

nuclear receptor subfamily 4 group A member 2

Gene Symbol

NR4A2

HGNC ID

HGNC:7981

ORF Size (aa)

1608

ORF Size (bp)

1608 bp

RefSeq ID

NM_006186

RefSeq Synonyms

NM_006186, BC066890, BC009288,

Species

human

UniGene ID

Hs.563344

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.