human NR1I2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NR1I2.
shAAV-217039
AAV-h-NR1I2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NR1I2 (nuclear receptor subfamily 1 group I member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
Description (Vector)
NR1I2 product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Gene ID
8856
Gene Name (Vector)
nuclear receptor subfamily 1 group I member 2
Gene Symbol
NR1I2
HGNC ID
HGNC:7968
ORF Size (aa)
1302
ORF Size (bp)
1302 bp
RefSeq ID
NM_003889
RefSeq Synonyms
NM_033013, NM_022002, NM_003889, BC017304,
Species
human
UniGene ID
Hs.7303
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.