human NPY shRNA silencing AAV

Name
AAV-h-NPY-shRNA

Cat No
shAAV-217017

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NPY.

shAAV-217017

AAV-h-NPY-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NPY (neuropeptide Y). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PYY4

Description (Vector)

NPY encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.

Gene ID

4852

Gene Name (Vector)

neuropeptide Y

Gene Symbol

NPY

HGNC ID

HGNC:7955

ORF Size (aa)

294

RefSeq ID

NM_000905

RefSeq Synonyms

NM_000905, BC029497,

Species

human

UniGene ID

Hs.1832

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.