human NPTX2 shRNA silencing AAV

Name
AAV-h-NPTX2-shRNA

Cat No
shAAV-217009

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NPTX2.

shAAV-217009

AAV-h-NPTX2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NPTX2 (neuronal pentraxin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NARP; NP-II; NP2

Description (Vector)

NPTX2 encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.

Gene ID

4885

Gene Name (Vector)

neuronal pentraxin 2

Gene Symbol

NPTX2

HGNC ID

HGNC:7953

ORF Size (aa)

1296

ORF Size (bp)

1296 bp

RefSeq ID

NM_002523

RefSeq Synonyms

NM_002523, BC048275, BC035339, BC034781, BC009924,

Species

human

UniGene ID

Hs.3281

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.