human NPHP3 shRNA silencing AAV

Name 
AAV-h-NPHP3-shRNA
Cat No 
shAAV-216959
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NPHP3.

shAAV-216959
AAV-h-NPHP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NPHP3 (nephrocystin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
59
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3
Description (Vector)
NPHP3 encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene.
Gene ID
27031
Gene Name (Vector)
nephrocystin 3
Gene Symbol
NPHP3
HGNC ID
HGNC:7907
ORF Size (aa)
3990
ORF Size (bp)
3990 bp
RefSeq ID
NM_153240
RefSeq Synonyms
NM_153240, BC172279,
Species
human
UniGene ID
Hs.511991

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.