human NOTCH2 shRNA silencing AAV

AGS2; HJCYS; hN2; neurogenic locus notch homolog protein 2; Notch 2; Notch homolog 2

Notch2 is a member of the Notch family of transmembrane receptors. The Notch gene was first reported as a drosophila gene responsible for the presence of notches in the wingblades of a specific strain of flies. The Notch proteins mediate juxtacrine signals between adjacent cells and regulate cell fate determination during development. In mammals there are 4 Notch receptors (Notch 1-4). Like Notch1, Notch 2 is required for embryo viability. Although Notch1 and Notch 2 are functionally similar, they may not serve redundant functions in the cell.

NOTCH2 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

4853

notch 2

notch 2

NOTCH2

HGNC:7882

9606.0

3708

3708 bp

Neurogenic locus notch homolog protein 2

NM_024408

NM_024408, NM_001200001, BC071562,

Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Gene Expression,Golgi Apparatus,Immunology,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,Transcription Factor/Regulator

cancer,genetics,signal_transduction,cell_biology,cardiovascular,cell_cycle,genetics,transcription_translation,cell_biology,immunology,neurobiology,developmental_biology,signal_transduction,genetics,transcription_translation

human

Notch2 is a member of the Notch family of transmembrane receptors. The Notch gene was first reported as a drosophila gene responsible for the presence of notches in the wingblades of a specific strain of flies. The Notch proteins mediate juxtacrine signals between adjacent cells and regulate cell fate determination during development. In mammals there are 4 Notch receptors (Notch 1-4). Like Notch1, Notch 2 is required for embryo viability. Although Notch1 and Notch 2 are functionally similar, they may not serve redundant functions in the cell.

Hs.487360

Q04721