human NLRP2 shRNA silencing AAV

Name
AAV-h-NLRP2-shRNA

Cat No
shAAV-216798

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NLRP2.

shAAV-216798

AAV-h-NLRP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NLRP2 (NLR family pyrin domain containing 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CLR19.9; NALP2; NBS1; PAN1; PYPAF2

Description (Vector)

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 (PubMed 12563287)).(supplied by OMIM, Mar 2008)

Gene ID

55655

Gene Name (Vector)

NLR family pyrin domain containing 2

Gene Symbol

NLRP2

HGNC ID

HGNC:22948

ORF Size (aa)

2541

ORF Size (bp)

2541 bp

RefSeq ID

NM_017852

RefSeq Synonyms

NM_017852, NM_001174083, NM_001174082, NM_001174081, BC039269, BC003592, BC001039,

Species

human

UniGene ID

Hs.369279

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.