human NLRP12 shRNA silencing AAV

Name
AAV-h-NLRP12-shRNA

Cat No
shAAV-216793

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NLRP12.

shAAV-216793

AAV-h-NLRP12-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NLRP12 (NLR family pyrin domain containing 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2

Description (Vector)

NLRP12 encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.

Gene ID

91662

Gene Name (Vector)

NLR family pyrin domain containing 12

Gene Symbol

NLRP12

HGNC ID

HGNC:22938

ORF Size (aa)

3186

ORF Size (bp)

3186 bp

RefSeq ID

NM_144687

RefSeq Synonyms

NM_144687, NM_033297, NM_001277129, NM_001277126, BC028069,

Species

human

UniGene ID

Hs.631573

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.