human NLRP11 shRNA silencing AAV

Name 
AAV-h-NLRP11-shRNA
Cat No 
shAAV-216792
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NLRP11.

shAAV-216792
AAV-h-NLRP11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NLRP11 (NLR family pyrin domain containing 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CLR19.6; NALP11; NOD17; PAN10; PYPAF6; PYPAF7
Description (Vector)
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)).(supplied by OMIM, Mar 2008)
Gene ID
204801
Gene Name (Vector)
NLR family pyrin domain containing 11
Gene Symbol
NLRP11
HGNC ID
HGNC:22945
ORF Size (aa)
3102
ORF Size (bp)
3102 bp
RefSeq ID
NM_145007
RefSeq Synonyms
NM_145007, NM_001297743, BC034730,
Species
human
UniGene ID
Hs.375039

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.