human NLN shRNA silencing AAV

Name 
AAV-h-NLN-shRNA
Cat No 
shAAV-216785
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NLN.

shAAV-216785
AAV-h-NLN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NLN (neurolysin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AGTBP; angiotensin binding protein; Angiotensin-binding protein; endopeptidase 24.16; EP24.16; MEP; microsomal endopeptidase; mitochondrial oligopeptidase M; MOP; neurolysin (metallopeptidase M3 family); neurolysin, mitochondrial; neurotensin endopeptidase
Description (eCommerce)
Neurolysin is a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). Neurolysin is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract [taken from NCBI Entrez Gene (Gene ID: 57486)].
Description (Vector)
NLN encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.
Gene ID
57486
Gene Name (eCommerce)
neurolysin
Gene Name (Vector)
neurolysin
Gene Symbol
NLN
HGNC ID
HGNC:16058
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1824
ORF Size (bp)
1824 bp
Protein Name (eCommerce)
Neurolysin, mitochondrial
RefSeq ID
NM_020726
RefSeq Synonyms
NM_020726, BC004985, BC001644,
Research Areas
Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Neurolysin is a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). Neurolysin is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract [taken from NCBI Entrez Gene (Gene ID: 57486)].
UniGene ID
Hs.247460
UniProt ID (eCommerce)
Q9BYT8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.