human NFATC2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NFATC2.
shAAV-216631
AAV-h-NFATC2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NFATC2 (nuclear factor of activated T-cells 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NFAT pre-existing subunit; NFAT transcription complex, preexisting component; NFAT1; NFATc2; NF-ATc2; NFATP; NF-ATp; nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1
Description (eCommerce)
Nuclear factor of activated T cells 1(NFAT1) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFAT1 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. NFAT1 is a member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFAT1 and an inducible nuclear component NFAT2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13469].
Description (Vector)
NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Gene ID
4773
Gene Name (eCommerce)
nuclear factor of activated T cells 2
Gene Name (Vector)
nuclear factor of activated T-cells 2
Gene Symbol
NFATC2
HGNC ID
HGNC:7776
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2778
ORF Size (bp)
2778 bp
Protein Name (eCommerce)
Nuclear factor of activated T-cells, cytoplasmic 2
RefSeq ID
NM_012340
RefSeq Synonyms
NM_173091, NM_012340, NM_001258297, NM_001258296, NM_001258295, NM_001258294, NM_001258292, NM_001136021, BC144074, BC136418,
Research Areas
Axon Guidance,B-cell Receptor Signaling,Cardiac Development,Cardiology,Cardiovascular,Cytoskeleton,DNA Damage/Repair,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Neurobiology,NFAT Signaling,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
signal_transduction,neurobiology,immunology,cardiovascular,cell_biology,genetics,transcription_translation,signal_transduction,immunology,infectious_disease,immunology,neurobiology,signal_transduction,genetics,transcription_translation,developmental_biology
Species
human
Target Sentence
Nuclear factor of activated T cells 1(NFAT1) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFAT1 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. NFAT1 is a member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFAT1 and an inducible nuclear component NFAT2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13469].
UniGene ID
Hs.713650
UniProt ID (eCommerce)
Q13469
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.