human NFATC1 shRNA silencing AAV

Name
AAV-h-NFATC1-shRNA

Cat No
shAAV-216628

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NFATC1.

shAAV-216628

AAV-h-NFATC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NFATC1 (nuclear factor of activated T-cells 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NFAT transcription complex cytosolic component; NFAT2; NFATc; NF-ATC; NFATc1; NF-ATc1; NF-ATc1.2; nuclear factor of activated T-cells 'c'; nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Description (eCommerce)

Nuclear factor of activated T cells, cytoplasmic 1(NFATc1) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFATc1 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription.

Description (Vector)

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Gene ID

4772

Gene Name (eCommerce)

nuclear factor of activated T cells 1

Gene Name (Vector)

nuclear factor of activated T-cells 1

Gene Symbol

NFATC1

HGNC ID

HGNC:7775

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2151

ORF Size (bp)

2151 bp

Protein Name (eCommerce)

Nuclear factor of activated T-cells, cytoplasmic 1

RefSeq ID

NM_006162

RefSeq Synonyms

NM_172390, NM_172389, NM_172388, NM_172387, NM_006162, NM_001278675, NM_001278673, NM_001278672, NM_001278670, NM_001278669, BC112243, BC104753,

Research Areas

Apoptosis,B-cell Receptor Signaling,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Fc Receptor Signaling,Gene Expression,Host-Virus Interactions,Immunology,Innate Immunity,MAPK Signaling,NFAT Signaling,RANKL-RANK Signaling,RNA Binding,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,Wnt Signaling

Research Areas (Faceted)

cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.701518

UniProt ID (eCommerce)

O95644

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.