human NEFH shRNA silencing AAV

Name 
AAV-h-NEFH-shRNA
Cat No 
shAAV-216558
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NEFH.

shAAV-216558
AAV-h-NEFH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NEFH (neurofilament heavy polypeptide). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
200 kDa neurofilament protein; CMT2CC; neurofilament heavy polypeptide; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa; NFH; NF-H
Description (eCommerce)
Neurofilaments are type IV intermediate filament heteropolymers composed of light (L), medium (M), and heavy (H) chains. Neurofilaments are a component of the axon cytoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. NF-H is commonly used as a biomarker of neuronal damage [taken from NCBI Entrez Gene (Gene ID: 4744)].
Description (Vector)
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
Gene ID
4744
Gene Name (eCommerce)
neurofilament heavy
Gene Name (Vector)
neurofilament heavy polypeptide
Gene Symbol
NEFH
HGNC ID
HGNC:7737
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3081
ORF Size (bp)
3081 bp
Protein Name (eCommerce)
Neurofilament heavy polypeptide
RefSeq ID
NM_021076
RefSeq Synonyms
NM_021076, BC073969,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Cytoskeleton,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology
Species
human
Target Sentence
Neurofilaments are type IV intermediate filament heteropolymers composed of light (L), medium (M), and heavy (H) chains. Neurofilaments are a component of the axon cytoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. NF-H is commonly used as a biomarker of neuronal damage [taken from NCBI Entrez Gene (Gene ID: 4744)].
UniGene ID
Hs.198760
UniProt ID (eCommerce)
P12036

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.