human NEBL shRNA silencing AAV

Name
AAV-h-NEBL-shRNA

Cat No
shAAV-216541

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NEBL.

shAAV-216541

AAV-h-NEBL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NEBL (nebulette). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LASP2; LNEBL

Description (Vector)

NEBL encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants.

Gene ID

10529

Gene Name (Vector)

nebulette

Gene Symbol

NEBL

HGNC ID

HGNC:16932

ORF Size (aa)

3045

ORF Size (bp)

3045 bp

RefSeq ID

NM_006393

RefSeq Synonyms

NM_213569, NM_006393, NM_001173484, BC110453, BC110452,

Species

human

UniGene ID

Hs.5025

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.