human NDUFV1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NDUFV1.
shAAV-216535
AAV-h-NDUFV1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CI-51K; CI51KD; UQOR1
Description (Vector)
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
4723
Gene Name (Vector)
NADH:ubiquinone oxidoreductase core subunit V1
Gene Symbol
NDUFV1
HGNC ID
HGNC:7716
ORF Size (aa)
1368
ORF Size (bp)
1368 bp
RefSeq ID
NM_007103
RefSeq Synonyms
NM_007103, NM_001166102, BC015645, BC008146,
Species
human
UniGene ID
Hs.7744
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.