human NDP shRNA silencing AAV

Name
AAV-h-NDP-shRNA

Cat No
shAAV-216455

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NDP.

shAAV-216455

AAV-h-NDP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NDP (NDP, norrin cystine knot growth factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EVR2; FEVR; ND

Description (Vector)

NDP encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy.

Gene ID

4693

Gene Name (Vector)

NDP, norrin cystine knot growth factor

Gene Symbol

NDP

HGNC ID

HGNC:7678

ORF Size (aa)

402

RefSeq ID

NM_000266

RefSeq Synonyms

NM_000266, BC029901,

Species

human

UniGene ID

Hs.522615

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.