human NDC80 shRNA silencing AAV

Name 
AAV-h-NDC80-shRNA
Cat No 
shAAV-216442
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NDC80.

shAAV-216442
AAV-h-NDC80-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NDC80 (NDC80, kinetochore complex component). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HEC; HEC1; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; retinoblastoma-associated protein HEC; TID3
Description (eCommerce)
HEC1 (highly expressed in cancer 1) is a component of the kinetochore-associated NDC80 complex that is essential for maintaining kinetochore integrity, proper chromosome segregation, and spindle-checkpoint signaling. HEC1 has been shown to be required for the organization of kinetochore microtubule attachment sites.
Description (Vector)
NDC80 encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
Gene ID
10403
Gene Name (eCommerce)
NDC80, kinetochore complex component
Gene Name (Vector)
NDC80, kinetochore complex component
Gene Symbol
NDC80
HGNC ID
HGNC:16909
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1929
ORF Size (bp)
1929 bp
Protein Name (eCommerce)
Kinetochore protein NDC80 homolog
RefSeq ID
NM_006101
RefSeq Synonyms
NM_006101, BC035617,
Research Areas
Cancer,Cell Cycle,Cell Division,PLK1 Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
HEC1 (highly expressed in cancer 1) is a component of the kinetochore-associated NDC80 complex that is essential for maintaining kinetochore integrity, proper chromosome segregation, and spindle-checkpoint signaling. HEC1 has been shown to be required for the organization of kinetochore microtubule attachment sites.
UniGene ID
Hs.414407
UniProt ID (eCommerce)
O14777

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.