human NCOA3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NCOA3.
shAAV-216420
AAV-h-NCOA3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NCOA3 (nuclear receptor coactivator 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACTR; AIB1; AIB-1; amplified in breast cancer 1 protein; bHLHe42; CAGH16; CBP-interacting protein; class E basic helix-loop-helix protein 42; CTG26; KAT13B; NCoA-3; nuclear receptor coactivator 3; pCIP; RAC3; RAC-3; receptor-associated coactivator 3; SRC3; SRC-3; steroid receptor coactivator protein 3; thyroid hormone receptor activator molecule 1; TNRC14; TNRC16; TRAM-1
Description (eCommerce)
Steroid receptor coactivator 3 (SRC3) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC3 is an oncogene that is reported to be amplified and/or overexpressed in breast and gastric cancer and stimulates AKT signaling and cell growth and tumorigenesis.
Description (Vector)
NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
Gene ID
8202
Gene Name (eCommerce)
nuclear receptor coactivator 3
Gene Name (Vector)
nuclear receptor coactivator 3
Gene Symbol
NCOA3
HGNC ID
HGNC:7670
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4269
ORF Size (bp)
4269 bp
Protein Name (eCommerce)
Nuclear receptor coactivator 3
RefSeq ID
NM_006534
RefSeq Synonyms
NM_181659, NM_006534, NM_001174088, NM_001174087, BC122547, BC119001, BC092516,
Research Areas
Acyltransferase,Breast Cancer,Cancer,EGFR Signaling,Estrogen Signaling,Gene Expression,Golgi Apparatus,Histone Modification,Immunology,Interleukin Signaling,Metabolism/Metabolic Process,Nuclear Receptor Coactivators,RNA Processing,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,genetics,transcription_translation,cell_biology,genetics,immunology,signal_transduction,metabolism,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Steroid receptor coactivator 3 (SRC3) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC3 is an oncogene that is reported to be amplified and/or overexpressed in breast and gastric cancer and stimulates AKT signaling and cell growth and tumorigenesis.
UniGene ID
Hs.592142
UniProt ID (eCommerce)
Q9Y6Q9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.