human NCF2 shRNA silencing AAV

Name
AAV-h-NCF2-shRNA

Cat No
shAAV-216398

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NCF2.

shAAV-216398

AAV-h-NCF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NCF2 (neutrophil cytosolic factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NCF-2; NOXA2; P67-PHOX; P67PHOX

Description (Vector)

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

4688

Gene Name (Vector)

neutrophil cytosolic factor 2

Gene Symbol

NCF2

HGNC ID

HGNC:7661

ORF Size (aa)

1581

ORF Size (bp)

1581 bp

RefSeq ID

NM_000433

RefSeq Synonyms

NM_001190794, NM_001190789, NM_001127651, NM_000433, BC001606,

Species

human

UniGene ID

Hs.587558

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.