human NANS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NANS.
shAAV-216303
AAV-h-NANS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NANS (N-acetylneuraminate synthase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HEL-S-100; SAS; SEMDCG; SEMDG
Description (Vector)
NANS encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. NANS is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.
Gene ID
54187
Gene Name (Vector)
N-acetylneuraminate synthase
Gene Symbol
NANS
HGNC ID
HGNC:19237
ORF Size (aa)
1080
ORF Size (bp)
1080 bp
RefSeq ID
NM_018946
RefSeq Synonyms
NM_018946, BC019315, BC000008,
Species
human
UniGene ID
Hs.665191
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.