human MYO5A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MYO5A.
shAAV-216220
AAV-h-MYO5A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MYO5A (myosin VA). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GS1; MYH12; MYO5; MYR12
Description (Vector)
MYO5A is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
Gene ID
4644
Gene Name (Vector)
myosin VA
Gene Symbol
MYO5A
HGNC ID
HGNC:7602
ORF Size (aa)
5565
ORF Size (bp)
5565 bp
RefSeq ID
NM_000259
RefSeq Synonyms
NM_001142495, NM_000259, BC172485, BC156392,
Species
human
UniGene ID
Hs.596221
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.