human MYH7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MYH7.
shAAV-216169
AAV-h-MYH7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MYH7 (myosin heavy chain 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM
Description (Vector)
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
Gene ID
4625
Gene Name (Vector)
myosin heavy chain 7
Gene Symbol
MYH7
HGNC ID
HGNC:7577
ORF Size (aa)
5808
ORF Size (bp)
5808 bp
RefSeq ID
NM_000257
RefSeq Synonyms
NM_000257, BC112173, BC112171,
Species
human
UniGene ID
Hs.678918
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.