human MYBPC3 shRNA silencing AAV

Name
AAV-h-MYBPC3-shRNA

Cat No
shAAV-216131

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MYBPC3.

shAAV-216131

AAV-h-MYBPC3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MYBPC3 (myosin binding protein C, cardiac). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CMD1MM; CMH4; FHC; LVNC10; MYBP-C

Description (Vector)

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

Gene ID

4607

Gene Name (Vector)

myosin binding protein C, cardiac

Gene Symbol

MYBPC3

HGNC ID

HGNC:7551

ORF Size (aa)

3825

ORF Size (bp)

3825 bp

RefSeq ID

NM_000256

RefSeq Synonyms

NM_000256, BC151211, BC142685, BC136546, BC136543,

Species

human

UniGene ID

Hs.524906

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.