human MVP shRNA silencing AAV

Name 
AAV-h-MVP-shRNA
Cat No 
shAAV-216095
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MVP.

shAAV-216095
AAV-h-MVP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MVP (major vault protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LRP; lung resistance-related protein; major vault protein; MVP; testicular secretory protein Li 30; VAULT1
Description (eCommerce)
Major Vault Protein (MVP) is the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport and may act as scaffolds for proteins involved in signal transduction. The encoded protein, also known as lung resistance-related protein (LRP), plays a role in multidrug resistance and expression of this gene may be a prognostic marker for several types of cancer [taken from NCBI Entrez Gene (Gene ID: 9961)].
Description (Vector)
MVP encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Gene ID
9961
Gene Name (eCommerce)
major vault protein
Gene Name (Vector)
major vault protein
Gene Symbol
MVP
HGNC ID
HGNC:7531
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2682
ORF Size (bp)
2682 bp
Protein Name (eCommerce)
Major vault protein
RefSeq ID
NM_005115
RefSeq Synonyms
NM_017458, NM_005115, NM_001293205, NM_001293204, BC015623,
Research Areas
EGFR Signaling,mRNA transport,RNA Transport,Signal Transduction
Research Areas (Faceted)
signal_transduction,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Major Vault Protein (MVP) is the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport and may act as scaffolds for proteins involved in signal transduction. The encoded protein, also known as lung resistance-related protein (LRP), plays a role in multidrug resistance and expression of this gene may be a prognostic marker for several types of cancer [taken from NCBI Entrez Gene (Gene ID: 9961)].
UniGene ID
Hs.632177
UniProt ID (eCommerce)
Q14764

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.